Incilius alvarius — commonly known as the Colorado River toad or Sonoran Desert toad — is an amphibian native to northern Mexico and the southwestern United States, whose parotoid gland secretion contains 5-MeO-DMT, a potent short-acting tryptamine. Its rapid global popularization in ceremonial and therapeutic contexts has raised urgent concerns about animal welfare, ecological pressure on populations, biocultural rights and safety. ICEERS gathers here scientific, ethical and policy content on Incilius alvarius and the 5-MeO-DMT it contains.