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All ICEERS’ studies are peer-reviewed, published in indexed and high-impact journals and follow the strictest methodological and ethical standards.
The authors emphasize the importance of developing and validating models and methods for psychedelic integration practices that help users of psychedelics to process and integrate their experiences into their daily lives.
The paper provides a detailed review of the pharmacological actions of ibogaine and its metabolite noribogaine, highlighting their potential in treating substance use disorders.
The authors propose community or peer-based structures as a viable means to control the supply of psilocybin-containing mushrooms and ensure a safe environment for non-medical use.
The COVID-19 pandemic has had a devastating impact on the health and wellbeing of the global population. This paper presents the results of a longitudinal transcultural study that was begun at the peak of the pandemic (in April, 2020).
This study explores the potential therapeutic effects of ayahuasca and cannabidiol (CBD) on social cognition and interactions.
This study examines the qualitative aspects of ayahuasca integration experiences based on survey responses from 1630 individuals worldwide.
This study proposes that, in light of historical, epidemiological, and scientific research, hallucinations can be better characterized as a common phenomenon associated sometimes with psychopathology but also with functional and even beneficial outcomes.
The study was conducted during the global social confinement measures related to the COVID-19 pandemic to support the development of better strategies for stress management and the protection of mental health during future events.
In this letter to the editor, the authors suggest that the well-established research with natural products can offer valuable insights for hallucinogen researchers, as they remain one of the main sources for the development of pharmaceuticals.
In this manuscript, we present the main methodological issues in psychedelic research, ranging from the most manageable (e.g., non-representative samples) to the most complex (e.g., limitations of the biomedical model).
This study explores historical and recent literature regarding endogenous DMT, with a special interest in the most controversial topics. It also delves into technical aspects that are not discussed in other reviews, in order to offer new insights.
We have analyzed all randomized, double-blind, and controlled trials that assessed the antidepressant effects of psilocybin and LSD in clinical populations to date.
One of the main public health strategies adopted at the beginning of the COVID-19 pandemic consisted of implementing strict lockdowns to stop the transmission of the virus. Despite being an effective measure, the confinement and the associated social isolation create a stressful, potentially lengthy situations that has been proven to have several psychological consequences. Given the potential benefits that certain psychedelic drugs have shown for the treatment of psychological disorders, this study aimed to assess the impact of lifetime psychedelic drug use on mental health in relation to the first strict lockdown adopted by various countries (April-July 2020).
The volume of research on the therapeutic use of psychedelic drugs has been increasing during the last decades. Partly because of the need of innovative treatments in psychiatry, several studies have assessed the safety and efficacy of drugs like psilocybin or ayahuasca for a wide range of mental disorders, including major depression.
In order to summarize the current evidence on microdosing and help future studies, this study presents a systematic review exploring issues like the safety of microdosing, main reported benefits, and what aspects of these benefits might be attributed to a placebo effect.
On Sep 28, 2020, Maja Kohek and others published “Psychedelics in times of pandemic outbreaks,” a chapter of the book RESET: Reflexiones antropológicas ante la pandemia de COVID-19, where the authors propose considering the potential of psychedelics to help people deal with some of the challenges that we are facing in pandemic times.
The need for innovative treatments in psychiatry could be responded to in part through the greater introduction of psychedelic psychotherapies, as they represent an integrative approach to mental health, involving the use of pharmacological tools that can be combined with enhanced psychotherapeutic interventions.
In this commentary, we expand the information available on the original article by briefly reviewing data from recent placebo-controlled, double-blind, cross-over clinical trials showing evidence that administration of single (or few) doses of LSD and psilocybin was associated with rapid and sustained reductions in depressive and anxiety symptoms in patients with end-stage cancer and other life-threatening diseases (e.g., Bechterew’s disease, Parkinson’s disease, Celiac disease).
In order to study the patterns of use, the desired effects and the mental health status of individuals who make use of natural psychoactive drugs, ICEERS conducted detailed research through an online questionnaire that collected responses from 564 NPD users from 52 different countries.
Recent preclinical and clinical studies have demonstrated the potential of serotoninergic hallucinogens in the treatment of mood and anxiety disorders and drug dependence. Thus, the purpose of this study was to present a systematic review of the effects of these substances in the recognition of facial expressions, which is one of the main factors involved in social cognition.
A more integrative treatment is required that combines pharmacological tools with psychosocial interventions. Psychedelic-assisted psychotherapy could satisfy this need, offering pharmacological action along with enhanced psychotherapeutic interventions.
This study summarizes the most compelling evidence from clinical research with serotonergic psychedelics, performing a systematic review of systematic reviews where efficacy, tolerability, and safety have been assessed regarding the management of mood, anxiety, and substance-use disorders.
Psychedelics can have a positive impact on some dimensions of personality traits, opening a new field of therapeutic possibilities, where personality and associated brain modifications could be the basis of future therapeutic change.
Serotonergic psychedelics act as agonists at cortical 5-HT2A receptors, expressed in fronto-temporo-parieto-occipital areas. This study reviews all previous scientific literature regarding the effects of serotonergic psychedelics in modulating users’ personality.
The subjective effects of psychedelic drugs are probably their most difficult aspect to measure. Therefore, we used novel psychometric data for the MEQ, HRS, and ARCI questionnaires, proposing preliminary new versions and/or alternative interpretations of the data.
This study aimed to obtain preliminary evidence about the possible relationship, in the realm of subjective effects, between ketamine sessions and near-death experiences. As ketamine produces dissociative experiences, the possible relationships between its use and the possible occurrence of post-traumatic symptomatology are also explored.
Psychedelic agents have a long history of use by humans for their capacity to induce profound modifications in perception, emotion and cognitive processes. Despite increasing knowledge of the neural mechanisms involved in the acute effects of these drugs, the impact of sustained psychedelic use on the human brain remains largely unknown. Molecular pharmacology studies have shown that psychedelic 5-hydroxytryptamine (5HT)2A agonists stimulate neurotrophic and transcription factors associated with synaptic plasticity. These data suggest that psychedelics could potentially induce structural changes in brain tissue.
This study compares the metabolism and disposition of DMT in a sample of recreational users. Urine samples were obtained after intake via two different administration routes: oral ingestion, and smoked intake.
Ethnobotanical hallucinogens are tools that serve to establish bridges between cultures, producing a mutual enrichment between the cultures where the use of these plants originated and those in which they are being implanted.
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Ayahuasca Technical Report
26 pages with all the latest research-based facts about ayahuasca, its uses, pharmacology, legal status and therapeutic effects, signed by 11 world-class experts and researchers.
